Brain Tumors & The Usage Of A Two-Drug Tandem

By Robbie Sutter


When studying brain tumors and what can be done in order to slow their progression, at the very least, certain drugs will be focused on. Some of these may have been utilized to help other conditions in the past while another group of drugs may be entirely unique. Whatever the case may be, it's apparent that some of them will leave greater impacts than others, not only in the medical field but amongst patients as well. Could a potential two-drug combination help to expand results even further?

YottaFire put forth an article that went into detail about a combination of drugs that could come into play in order to stop the progression of brain tumors. A group of mice was focused on, seeing as how each of the test subjects had the condition in question. Following the administration of the drug tandem, it was found that their survival rates had become that much better. To me, this is just one of the reasons as to why this story should be focused on by many organizations, Voices against Brain Cancer included.

Researchers at the Dana-Farber Cancer Institute conducted the study while utilizing two drugs that would, in theory, be able to control the actions associated with glioblastoma. Keep in mind that a similar study was done in the past, focusing on one pathway, but the results that came about was not successful. With this method, though, two cell signaling pathways have been given focus. This is an improvement, to be certain, but I feel as though there should be focus given on a genetic abnormality that is common in around one-third of glioblastoma patients.

These patients, from what I have gathered, seem to lack a certain gene by the name of PTEN. This may not be a common name to most but be certain that this gene works as something of a tumor-suppressant. If PTEN is not seen in the body, an excessive amount of molecular growth can occur, which means that the malignant rate of said growth can reach the brain as well. It is uncertain if PTEN can be replaced but the drug combination spoken about before can halt the level of growth seen.

With this in mind, it is important to make note of all of the occurrences that can be seen in the human body. Not all of them are going to make sense but it's apparent that they work together in order to create order. When a single element is out of place, though, the risk for contracting a condition can increase; this was proven by the potential lack of the PTEN gene. With certain drugs coming together and then going on to become implemented, though, the research focused on brain tumors can be given more essential information.




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